LI-FRAUMENI SYNDROME

Li-Fraumeni Syndrome (LFS) is linked to a mutation in the TP53 tumor suppressor gene.

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Li-Fraumeni Syndrome Support Group

Click here to join a private Facebook support group specifically for those living with LFS. A place to share, ask questions and learn from the experiences of others who are just like you.

Li-Fraumeni Syndrome Family & Friends

Click here to join a private Facebook support group for family members and friends to learn how to support their loved ones who are living with LFS.

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Latest Blog Posts

Choroid Plexus Brain Tumors are highly associated with Li-Fraumeni Syndrome. The choroid plexus is within each ventricle in the brain; a series of vessels and tissue that are responsible for making cerebrospinal fluid that takes impurities and waste away. Tumors that grow here can block the flow of fluid and cause hydrocephalus (swelling in the brain). Choroid plexus tumors are very rare, they make up less than 1% of all brain tumors. Yet,  greater than 85% of choroid plexus tumors occur … read more

by Andi Last, Living LFS Secretary & Media Relations – I am part of a group of people with a rare genetic condition called Li-Fraumeni Syndrome (LFS). You’ve heard of the infamous BRCA, “the breast cancer gene?” LFS is like BRCA on crack. Men with LFS have a 73% lifetime chance of developing cancer. For women with LFS, the lifetime chance of developing cancer is nearly 100%. LFS “core” cancers are breast, brain, sarcoma and adrenocortical, but LFS can cause … read more